Breakpoint clustering in t(4;11)(q21;q23) acute leukemia
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چکیده
منابع مشابه
Breakpoint Clustering in t ( 4 ; l l ) ( q 21 ; q 23 ) Acute Leukemia
Chromosome 11 band q23 is commonly involved in nonrandom chromosomal translocations in hematopoietic malignancies, especially in infant acute leukemias. By using pulsedfield gel electrophoresis (PFGE) with restriction endonuclease digests of DNA from both a leukemia cell line (RS4;ll) bearing the t(4;l l)(q21;q23) and from human/ hamster hybrid cells, we have been able to construct a detailed r...
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DNA rearrangements caused by chromosome translocations between band 11q23 and various chromosomes can be detected by a single probe, B859, an 859-base pair complementary DNA fragment derived from the human ALL-1 gene. To try to understand why band 11q23 becomes a frequent target of the translocations, we have sequenced the entire breakpoint cluster region, a 8342-base pair BamHI genomic fragmen...
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DNA rearrangements caused by chromosometranslocations between band 11q23 and various chromosomes can be detected by a single probe, B859, an 859-base pair complementary DNA fragment derived from the human ALL-i gene. To try to understand why band 11q23 becomes a frequent target ofthe translocatlons,we have sequencedthe entire break point cluster region, a 8342-base pair BamHI genomic fragment d...
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Cytogenetic studies of acute monoblastic leukemia cases presenting MLL-MLLT10 (alias MLL-AF10) fusion show a broad heterogeneity of chromosomal breakpoints. We present two new pediatric cases (French-American-British type M5) with MLL-MLLT10 fusion, which we studied with fluorescence in situ hybridization. In both we detected a paracentric inversion of the 11q region that translocated onto chro...
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ژورنال
عنوان ژورنال: Blood
سال: 1991
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v78.10.2498.2498